EGFR gene copy number alteration and mutation are highly variable and scientists have been challenged to define their prognostic significance in triple-negative breast cancer.

EGFR基因拷贝数的改变和突变有很大的差异，科学家试图定义其在三阴性乳腺癌中的预后意义。

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DEFB gene products are small antimicrobial proinflammatory peptides, and copy number variation (CNV) could reasonably influence susceptibility to infection and inflammation.

DEFB基因产物是小分子抗菌肽，且拷贝数变化(CNV)可显著影响易感性及炎症反应。

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These deletions or duplications, also called copy-number changes, can change the dosage of a gene.

这些缺失或者是重复，也被称做是拷贝数的改变，能改变一个基因的数目。

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We counted the number of times we saw a copy of a gene in normal tissue and then in the diseased one, says David Searls, SmithKlines director of bioinformatics.

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